Everything about Betulinic Acid totally explained
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Betulinic acid is a naturally occurring pentacyclic
triterpenoid which has
anti-retroviral, anti-
malarial, and
anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of
topoisomerase. It is found in the
bark of several species of plants, including the
Ber tree (
Ziziphus mauritiana), the
white birch (
Betula pubescens), and many other plants such as the
tropical carnivorous plants Triphyophyllum peltatum and
Ancistrocladus heyneanus,
Diospyros leucomelas a member of the
persimmon family,
Tetracera boiviniana, the jambul (
Syzygium formosanum), flowering quince (
Chaenomeles sinensis), and
Pulsatilla chinensis.
Anti-tumor activity
In 1995, betulinic acid was reported as a selective
inhibitor of human
melanoma.
Then it was demonstrated, that betulinic acid induces
apoptosis in human melanoma
in vitro and
in vivo model systems. Currently it's undergoing development with assistance from the
Rapid Access to Intervention Development program of the
National Cancer Institute. ) and malignant brain tumors,
ovarian carcinoma,
In contrast, epithelial tumors, such as
breast carcinoma,
colon carcinoma,
small cell lung carcinoma and
renal cell carcinoma as well as
T-cell leukemia cells were completely refractory to treatment with betulinic acid. On the other hand Rieber suggested that betulinic acid exerts its inhibitory effect on human metastatic melanoma partly by increasing p53.
The study also demonstrated preferential apoptotic effect of betulinic acid on C8161 metastatic melanoma cells, with greater DNA fragmentation and growth arrest and earlier loss of viability than their non-metastatic C8161/neo 6.3 counterpart.Study of combination of betulinic acid with γ-irradiation showed clearly additive effects, and indicates that they differ in their mode of action.
Further Information
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